521 research outputs found
Observation of an Excited Bc+ State
Using pp collision data corresponding to an integrated luminosity of 8.5 fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+Ï+Ï- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+) MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bcâ(2S31)+ state reconstructed without the low-energy photon from the Bcâ(1S31)+âBc+Îł decay following Bcâ(2S31)+âBcâ(1S31)+Ï+Ï-. A second state is seen with a global (local) statistical significance of 2.2Ï (3.2Ï) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+) MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date
Bose-Einstein correlations of same-sign charged pions in the forward region in pp collisions at âs=7 TeV
Bose-Einstein correlations of same-sign charged pions, produced in protonproton collisions at a 7 TeV centre-of-mass energy, are studied using a data sample collected
by the LHCb experiment. The signature for Bose-Einstein correlations is observed in the
form of an enhancement of pairs of like-sign charged pions with small four-momentum
difference squared. The charged-particle multiplicity dependence of the Bose-Einstein correlation parameters describing the correlation strength and the size of the emitting source
is investigated, determining both the correlation radius and the chaoticity parameter. The
measured correlation radius is found to increase as a function of increasing charged-particle
multiplicity, while the chaoticity parameter is seen to decreas
Measurement of the inelastic pp cross-section at a centre-of-mass energy of 13TeV
The cross-section for inelastic proton-proton collisions at a centre-of-mass energy of 13TeV is measured with the LHCb detector. The fiducial cross-section for inelastic interactions producing at least one prompt long-lived charged particle with momentum p > 2 GeV/c in the pseudorapidity range 2 < η < 5 is determined to be Ï acc = 62:2 ± 0:2 ± 2:5mb. The first uncertainty is the intrinsic systematic uncertainty of the measurement, the second is due to the uncertainty on the integrated luminosity. The statistical uncertainty is negligible. Extrapolation to full phase space yields the total inelastic proton-proton cross-section Ï inel = 75:4 ± 3:0 ± 4:5mb, where the first uncertainty is experimental and the second due to the extrapolation. An updated value of the inelastic cross-section at a centre-of-mass energy of 7TeV is also reported
Influence of the interaction between nodal fibroblast and breast cancer cells on gene expression
Our aim was to evaluate the interaction between breast cancer cells and nodal fibroblasts, by means of their gene expression profile. Fibroblast primary cultures were established from negative and positive lymph nodes from breast cancer patients and a similar gene expression pattern was identified, following cell culture. Fibroblasts and breast cancer cells (MDA-MB231, MDA-MB435, and MCF7) were cultured alone or co-cultured separated by a porous membrane (which allows passage of soluble factors) for comparison. Each breast cancer lineage exerted a particular effect on fibroblasts viability and transcriptional profile. However, fibroblasts from positive and negative nodes had a parallel transcriptional behavior when co-cultured with a specific breast cancer cell line. The effects of nodal fibroblasts on breast cancer cells were also investigated. MDA MB-231 cells viability and migration were enhanced by the presence of fibroblasts and accordingly, MDA-MB435 and MCF7 cells viability followed a similar pattern. MDA-MB231 gene expression profile, as evaluated by cDNA microarray, was influenced by the fibroblasts presence, and HNMT, COMT, FN3K, and SOD2 were confirmed downregulated in MDA-MB231 co-cultured cells with fibroblasts from both negative and positive nodes, in a new series of RT-PCR assays. In summary, transcriptional changes induced in breast cancer cells by fibroblasts from positive as well as negative nodes are very much alike in a specific lineage. However, fibroblasts effects are distinct in each one of the breast cancer lineages, suggesting that the inter-relationships between stromal and malignant cells are dependent on the intrinsic subtype of the tumor
Updated Determination of Dâ°âDÂŻâ°Mixing and CP Violation Parameters with Dâ°âKâșÏâ» Decays
We report measurements of charm-mixing parameters based on the decay-time-dependent ratio of Dâ°âKâșÏâ» to Dâ°âKâ»Ïâș rates. The analysis uses a data sample of proton-proton collisions corresponding to an integrated luminosity of 5.0ââfbâ»Âč recorded by the LHCb experiment from 2011 through 2016. Assuming charge-parity (CP) symmetry, the mixing parameters are determined to be xâČÂČ=(3.9±2.7)Ă10â»â”, yâČ=(5.28±0.52)Ă10â»Âł, and R[subscript D]=(3.454±0.031)Ă10â»Âł. Without this assumption, the measurement is performed separately for Dâ° and D[over ÂŻ]â° mesons, yielding a direct CP-violating asymmetry A[subscript D]=(-0.1±9.1)Ă10â»Âł, and magnitude of the ratio of mixing parameters 1.00<|q/p|<1.35 at the 68.3% confidence level. All results include statistical and systematic uncertainties and improve significantly upon previous single-measurement determinations. No evidence for CP violation in charm mixing is observed
Observation of Dâ° Meson Decays to Î âșÏâ»ÎŒâșΌ⻠and KâșKâ»ÎŒâșΌ⻠Final States
The first observation of the Dâ°âÏâșÏâ»ÎŒâșΌ⻠and Dâ°âKâșKâ»ÎŒâșΌ⻠decays is reported using a sample of proton-proton collisions collected by LHCb at a center-of-mass energy of 8 TeV, and corresponding to 2ââfbâ»Âč of integrated luminosity. The corresponding branching fractions are measured using as normalization the decay Dâ°âKâ»Ïâș[ÎŒâșÎŒâ»][subscript Ïâ°/Ï], where the two muons are consistent with coming from the decay of a Ïâ° or Ï meson. The results are B(Dâ°âÏâșÏâ»ÎŒâșÎŒâ»)=(9.64±0.48±0.51±0.97)Ă10â»â· and B(Dâ°âKâșKâ»ÎŒâșÎŒâ»)=(1.54±0.27±0.09±0.16)Ă10â»â·, where the uncertainties are statistical, systematic, and due to the limited knowledge of the normalization branching fraction. The dependence of the branching fraction on the dimuon mass is also investigated
Angular moments of the decay Î <sub>b</sub> <sup>0</sup> âââÎÎŒ<sup>+</sup>ÎŒ<sup>â</sup> at low hadronic recoil
An analysis of the angular distribution of the decay Î âââÎΌΌ is presented, using data collected with the LHCb detector between 2011 and 2016 and corresponding to an integrated luminosity of approximately 5 fb. Angular observables are determined using a moment analysis of the angular distribution at low hadronic recoil, corresponding to the dimuon invariant mass squared range 15 < q < 20 GeV/c. The full basis of observables is measured for the first time. The lepton-side, hadron-side and combined forward-backward asymmetries of the decay are determined to be \begin{array}{l}{A}_{\mathrm{FB}}^{\ell }=-0.39\pm 0.04\left(\mathrm{stat}\right)\pm 0.01\left(\mathrm{syst}\right),\hfill \\ {}{A}_{\mathrm{FB}}^h=-0.30\pm 0.05\left(\mathrm{stat}\right)\pm 0.02\left(\mathrm{syst}\right),\hfill \\ {}{A}_{\mathrm{FB}}^{\ell h}=+0.25\pm 0.04\left(\mathrm{stat}\right)\pm 0.01\left(\mathrm{syst}\right).\hfill \end{array} An analysis of the angular distribution of the decay is presented, using data collected with the LHCb detector between 2011 and 2016 and corresponding to an integrated luminosity of approximately . Angular observables are determined using a moment analysis of the angular distribution at low hadronic recoil, corresponding to the dimuon invariant mass squared range . The full basis of observables is measured for the first time. The lepton-side, hadron-side and combined forward-backward asymmetries of the decay are determined to be \begin{align} A_{FB}^{l} & = -0.39 \pm 0.04\,\rm{stat} \pm 0.01\, \rm{syst}, \nonumber\\ A_{FB}^{h} & = -0.30 \pm 0.05\,\rm{stat} \pm 0.02\, \rm{syst}, \nonumber\\ A_{FB}^{lh} & = +0.25 \pm 0.04\,\rm{stat} \pm 0.01\, \rm{syst}. \nonumber \end{align} The measurements are consistent with Standard Model predictions
Measurement of CP observables in B± â D(â)K± and B± â D(â)ϱ decays
Measurements of CP observables in B ± âD (â) K ± and B ± âD (â) Ï Â± decays are presented, where D (â) indicates a neutral D or D â meson that is an admixture of D (â)0 and DÂŻ (â)0 states. Decays of the D â meson to the DÏ 0 and DÎł final states are partially reconstructed without inclusion of the neutral pion or photon, resulting in distinctive shapes in the B candidate invariant mass distribution. Decays of the D meson are fully reconstructed in the K ± Ï â , K + K â and Ï + Ï â final states. The analysis uses a sample of charged B mesons produced in pp collisions collected by the LHCb experiment, corresponding to an integrated luminosity of 2.0, 1.0 and 2.0 fb â1 taken at centre-of-mass energies of s=7, 8 and 13 TeV, respectively. The study of B ± âD â K ± and B ± âD â Ï Â± decays using a partial reconstruction method is the first of its kind, while the measurement of B ± âDK ± and B ± âDÏ Â± decays is an update of previous LHCb measurements. The B ± âDK ± results are the most precise to date
Measurement of the branching fraction and CP asymmetry in B plus . J/.. plus decays
The branching fraction and direct asymmetry of the decay
are measured using proton-proton collision
data collected with the LHCb detector at centre-of-mass energies of 7 and 8
TeV, corresponding to a total integrated luminosity of 3\mbox{fb}^{-1}. The
following results are obtained: \begin{align} \mathcal{B}(B^{+}\rightarrow
J/\psi \rho^{+}) &= (3.81 ^{+0.25}_{-0.24} \pm 0.35) \times 10^{-5}, \nonumber
\\ \mathcal{A}^{C\!P} (B^{+}\rightarrow J/\psi \rho^{+}) &=
-0.045^{+0.056}_{-0.057} \pm 0.008, \nonumber \end{align} where the first
uncertainties are statistical and the second systematic. Both measurements are
the most precise to date.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2018-036.htm
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